RESUMO
Epidermolysis bullosa (EB) is an inherited skin disease representing a spectrum of rare genetic disorders. These conditions share the common trait that causes fragile skin, resulting in the development of blisters and erosions. The inheritance follows an autosomal pattern, and the array of clinical presentations leads to significant physical suffering, considerable morbidity, and mortality. Despite EB having no cure, effectively managing EB remains an exceptional challenge due to its rarity and complexity, occasionally casting a profound impact on the lives of affected individuals. Considering that EB management requires a multidisciplinary approach, this sometimes worsens the condition of patients with EB due to inappropriate handling. Thus, more appropriate and precise treatment management of EB is essentially needed. Advanced technology in medicine and health comes into the bioinformatics era. Including treatment for skin diseases, omics-based approaches aim to evaluate and handle better disease management and treatment. In this work, we review several approaches regarding the implementation of omics-based technology, including genetics, pathogenic mutation, skin microbiomics, and metagenomics analysis for EB. In addition, we highlight recent updates on the potential of metagenomics analysis in precision medicine for EB.
RESUMO
The transmission growth rate of infectious diseases, particularly COVID-19, has forced governments to take immediate control decisions. Previous studies have shown that human mobility, weather condition, and vaccination are potential factors influencing virus transmission. This study investigates the contribution of weather conditions, namely temperature and precipitation, human mobility, and vaccination to coronavirus transmission. Three machine learning models: random forest (RF), XGBoost, and neural networks, are applied to predict the confirmed cases based on three aforementioned variables. All models' prediction are evaluated via spatial and temporal analysis. The spatial analysis observes the model performance over countries on certain times. The temporal analysis looks at the model prediction of each country during the specified period. The models' prediction results effectively indicate the transmission trend. The RF model performs best with a coefficient of determination of up to 89%. Meanwhile, all models confirm that vaccination is most significantly associated with COVID-19 cases.
